Effect of CPAP therapy on kidney function in patients with chronic kidney disease: a pilot randomized controlled trial.

Effect of CPAP therapy on kidney function in patients with chronic kidney disease: a pilot randomized controlled trial. Chest. 2020 Dec 11;: Authors: Rimke AN, Ahmed SB, Turin TC, Pendharkar SR, Raneri JK, Lynch EJ, Hanly PJ Abstract BACKGROUND: Obstructive sleep apnea (OSA) is common in chronic kidney disease (CKD) and may accelerate a decline in kidney function. It is not clear whether treatment of OSA with continuous positive airway pressure (CPAP) improves kidney function. RESEARCH QUESTION: Does treatment with CPAP improve kidney function in patients with CKD and co-existing OSA? STUDY DESIGN AND METHODS: A randomized, controlled, non-blinded, parallel clinical trial was performed on patients with stages 3 and 4 CKD and co-existing OSA comparing the effect of CPAP versus usual care on the estimated glomerular filtration rate (eGFR) and the urine albumin:creatinine ratio (ACR) over 12 months. RESULTS: Fifty seven patients were enrolled and 30 were randomized to CPAP. They had moderately severe CKD (eGFR 38.4 ± 1.5 mL/min/1.73 m2) and significant OSA and nocturnal hypoxemia (oxygen desaturation index 23.9 (20.3) events/hour; mean SpO2 89.5 (1.7)%); 60% had baseline albuminuria (ACR > 3 mg/mmol). There was no significant difference between CPAP and usual care in the change in eGFR and ACR over 12 months. Although there was some improvement in eGFR with CPAP therapy in patients with a lower risk of CKD pr...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research