Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.

CONCLUSIONS: Secretory cells dominate CFTR expression and function in human airway superficial epithelia. CFTR therapies may need to restore CFTR function to multiple cell types, with a focus on secretory cells.
PMID: 33321047 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2020 Category: Respiratory Medicine Authors: Okuda K, Dang H, Kobayashi Y, Carraro G, Nakano S, Chen G, Kato T, Asakura T, Gilmore RC, Morton LC, Lee RE, Mascenik T, Yin WN, Barbosa Cardenas SM, O'Neal YK, Minnick CE, Chua M, Quinney NL, Gentzsch M, Anderson CW, Ghio A, Matsui H, Nagase T, Ostrowski Tags: Am J Respir Crit Care Med Source Type: research