Eritrea: Significant Reduction in TB Incidence Rate

[Shabait] Asmara, 15 December 2020 - Tuberculosis (TB) incidence rate in Eritrea has significantly reduced in the last 10 years, Sister Hiwet Neguse, head of national TB controlling program at the Ministry of Health stated.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news

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Immunometabolism is a burgeoning field of investigation in tuberculosis host defense, susceptibility, and pathophysiology. Unbiased approaches to studying tuberculosis have, as expected, confirmed that pathways of immunometabolism are crucial in these disease processes. In this issue of the JCI, Reichmann et al. studied carefully controlled human lymph node tuberculosis and uncovered Sphingosine kinase 1 as a druggable target of interest that could support the infected host. Future host-directed therapy research might seek to establish the different cellular consequences of sphingolipid pathway manipulation. Animal models ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSION Adjunctive doxycycline with standard anti-TB treatment suppressed pathological MMPs in PTB patients. Larger studies on adjunctive doxycycline to limit TB immunopathology are merited.TRIAL REGISTRATION ClinicalTrials.gov NCT02774993.FUNDING Singapore National Medical Research Council (NMRC/CNIG/1120/2014, NMRC/Seedfunding/0010/2014, NMRC/CISSP/2015/009a); the Singapore Infectious Diseases Initiative (SIDI/2013/013); National University Health System (PFFR-28 January 14, NUHSRO/2014/039/BSL3-SeedFunding/Jul/01); the Singapore Immunology Network Immunomonitoring platform (BMRC/IAF/311006, H16/99/b0/011, NRF2017_SIS...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Pulmonary cavitation is a hallmark of Mycobacterium tuberculosis (Mtb) infection that provides an immune-privileged niche for extracellular bacillary replication, which associates with increased transmission rates, drug resistance, and chronic lung dysfunction following antituberculous therapy (ATT). Inhibitors of matrix metalloproteinases (MMPs), which are induced by Mtb infection, have shown efficacy in preclinical models and improved microbiologic and immunopathologic outcomes. In this issue of the JCI, Hao Miow et al. performed a double-blind, randomized controlled trial exploring host-directed effects of the MMP inhib...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Condition:   Tuberculosis Intervention:   Sponsors:   Khyber Medical University Peshawar;   University of Reading;   TB Control Program Khyber Pakhtunkhwa Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Microbiology Biological Sciences Source Type: research
This study was aimed at exploring whether latent tuberculosis infection (LTBI) contributes to the pathogenesis of immune-mediated inflammatory diseases in a TB endemic setting. We screened 198 rheumatoid arthritis (RA) patients with tuberculin skin test (TST) and studied 61 (median DAS28-ESR = 6.3 ) who were positive. Whole blood T cell proliferative responses toMycobacterium tuberculosis (Mtb) membrane (MtM) antigens, including the latency-induced protein alpha crystallin (Acr), were determined by flow cytometry using Ki67 expression as the marker for nuclear proliferation. Serum antibody levels were determined by ELISA. ...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Tuberculosis (TB) is a chronic infectious disease mainly caused by Mycobacterium tuberculosis (MTB), but other members of the Mycobacterium tuberculosis complex (MTBC), especially Mycobacterium bovis (pyrazinamide-resistant organisms), may also be involved. Thus, the ability to rapidly detect and identify MTB from other MTBC members (e.g., M. bovis, Mycobacterium microti, Mycobacterium africanum) is essential for the prevention and treatment of TB. A novel diagnostic method for the rapid detection and differentiation of MTB, which employs multiplex loop-mediated isothermal amplification (mLAMP) combined with a nanoparticle...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
The patient is a 51-year-old  male from Mexico with no known significant past medical history who presented with several weeks of intermittent fevers, chills, night sweats, headaches and weight loss. Two months prior to this admission, headaches, fevers, chills and night sweats had begun. One week prior to this admission he had presented to another institution with a chief complaint of persistent headaches. At the outside hospital the patient was found to have a positive Quantiferon Gold test. An Acid-Fast Bacilli (AFB) smear collected from the sputum at that institution was negative and culture remained negative after 1 week.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Diagnostic Dilemma Source Type: research
CONCLUSIONS: Decreased T lymphocytes in APTB patients may cause compensatory activation of CD8+ T cells. Multifunctional CD4+ T cells in peripheral blood could migrate to the lungs under the action of CXCR3 and associated chemokine. Multifunctional CD4+ T cells and Multifunctional CD8+ T cells were of great significance in monitoring disease treatment.PMID:34333359 | DOI:10.1016/j.intimp.2021.107898
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research
Horm Mol Biol Clin Investig. 2021 Jul 30. doi: 10.1515/hmbci-2020-0096. Online ahead of print.ABSTRACTCOVID-19 is a global emergency with over 10 million cases and over 500, 000 deaths worldwide. The SARS CoV-2 is a RNA virus belonging to the family coronaviridae. It has high infectivity. The manifestations of the disease range from asymptomatic or mild symptoms to severe pneumonia and ARDS. The CT scan of lung shows consolidation and "Ground Glass Opacities". The persons with other comorbidities are considered to be at a higher rate of acquiring the infection. Asthma and other allergies have not been identified ...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
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