Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.

CONCLUSIONS: Our results provide evidence that TYROBP-APOE signaling does not require TREM2 and could be an initiating step in establishment of the disease-associated microglia (DAM) phenotype.
PMID: 33314529 [PubMed - as supplied by publisher]

Source: The Journal of Alzheimers Association - December 15, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research