JAK1/2 inhibition impairs the development and function of inflammatory dendritic epidermal cells in atopic dermatitis.

CAPSULE SUMMARY: JAK inhibitors show improvement of AD with favourable safety profile. However, the mechanistic role of JAK in inflammatory dendritic epidermal cells (IDEC) remains unclear. We demonstrate that JAK1/2 inhibition impairs generation and function of IDEC.

Source: Journal of Allergy and Clinical Immunology - December 15, 2020 Category: Allergy & Immunology Authors: Anna Sophie Klaeschen, Tim Joachim N ümm, Nadine Herrmann, Nicole Leib, Laura Maintz, Takashi Sakai, Joerg Wenzel, Thomas Bieber Source Type: research