Bending loss regularized network for nuclei segmentation in histopathology images.

BENDING LOSS REGULARIZED NETWORK FOR NUCLEI SEGMENTATION IN HISTOPATHOLOGY IMAGES.
Proc IEEE Int Symp Biomed Imaging. 2020 Apr;2020:258-262
Authors: Wang H, Xian M, Vakanski A
Abstract
Separating overlapped nuclei is a major challenge in histopathology image analysis. Recently published approaches have achieved promising overall performance on public datasets; however, their performance in segmenting overlapped nuclei are limited. To address the issue, we propose the bending loss regularized network for nuclei segmentation. The proposed bending loss defines high penalties to contour points with large curvatures, and applies small penalties to contour points with small curvature. Minimizing the bending loss can avoid generating contours that encompass multiple nuclei. The proposed approach is validated on the MoNuSeg dataset using five quantitative metrics. It outperforms six state-of-the-art approaches on the following metrics: Aggregate Jaccard Index, Dice, Recognition Quality, and Panoptic Quality.
PMID: 33312394 [PubMed]

Source: Proceedings - International Symposium on Biomedical Imaging - December 15, 2020 Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research