Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent

ConclusionMET was found to be cytotoxic in GBM cells in vitro only at high, clinically not relevant concentrations, where it was effective in inducing apoptosis and necrosis. Sensitizing effects were only observed in combination with doxorubicin, but not with TMZ, and are dependent on cell line and the applied drug concentration. Therefore, our findings do not support the use of MET in the treatment of GBM in combination with TMZ, as no sensitizing effect of MET was observed.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research