Scientists home in on reasons behind cancer drug trial disappointment

Scientists have discovered a 'hidden' mechanism which could explain why some cancer therapies which aim to block tumor blood vessel growth are failing cancer trials. The same mechanism could play the role in the bacterial or viral septic shock -- e.g. in Ebola fever -- by destabilizing the blood vessels.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Authors: Yoon SY, Lee MY, Yoon J, Kim HJ, Kim KH, Kim SH, Lee SC, Bae SB, Kim CK, Lee NS, Lee KT, Park SK, Hong DS, Won JH Abstract Background: Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE compared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer. Methods: This retrospective review of medical records was performed on 505 patients with histopathologically proven advanced stage pancreatic cancer, from January 2006 to December ...
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Conclusion: Lymphocyte subsets at diagnosis differ between patients with different specific subtypes of AML. A low proportion of NK cells is associated with adverse genetic abnormalities, whereas a high proportion is related to death before remission. However, the proportion of NK cells may not show independent correlations with survival. PMID: 30310785 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Authors: Cappell MS, Hader I, Amin M Abstract AIM: To systematically review liver disease associated with hemophagocytic lymphohistiocytosis (HLH), propose reasonable contraindications for liver transplantation for liver failure in HLH, and report an illustrative case. METHODS: Systematic review according to PRISMA guidelines of hepatic manifestations of HLH using computerized literature search via PubMed of articles published since 1980 with keywords ("hemophagocytic lymphohistiocytosis" or "HLH") AND ("liver" or "hepatic"). Two authors independently performed literature...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Authors: Raad II, Chaftari AM, Torres HA, Ayoub EM, Narouz LI, Bartek J, Hachem R Abstract Egypt has one of the highest prevalence rates of hepatitis C virus (HCV) in the world, mostly with genotype 4 that is highly associated with severe fibrosis. As a consequence, hepatocellular carcinoma has become the leading cause of cancer in this country. Mauritania is a highly endemic area for hepatitis B virus (HBV). HBV and HCV could both be iatrogenically transmitted through infected blood products, infected needles, and medical equipment improperly sterilized. Adequate and efficient healthcare and public health measures...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
In this study, gold nanocomposites containing Ganoderma lucidum polysaccharide (GLP-Au) efficiently induced dendritic cell (DC) activation, evident by the increase of CD80/CD86/CD40/MHCII, decrease of phagocytic ability and acid phosphatase activity, and increased cytokine transcription. GLP-Au significantly promoted the proliferation of CD4+ and CD8 + T cells in splenocytes. DC/T cell co-culture study proved that GLP-Au activation on DC directly resulted in T cell proliferation. GLP-Au exhibited strong inhibitory effects on 4T1 tumor growth and pulmonary metastasis when combined with doxorubicin. GLP-Au reco...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
CONCLUSION: Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with biopsy-proven node-positive breast cancer is accurate and reliable, but requires careful patient selection and optimal surgical techniques. PMID: 30311642 [PubMed - in process]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
CONCLUSION: Despite extensive research and promising preclinical studies, a definite further agent in addition to fluoropyrimidines that consistently improves response rate has yet to be found. PMID: 30311641 [PubMed - in process]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
Abstract Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC. Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry. Overexpression of p16 was observed in 81 (5.51%) of the 1470 cases, and HPV positive was present in 78 cases (5.31%...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 12 October 2018Source: Journal of Oral Biology and Craniofacial ResearchAuthor(s): Raturi Vijay Parshuram, Rajendra Kumar, Madanlal Bhatt, Rahul Singh, Devendra Parmar, Jalaj Gaur, Dewesh Kishan, Mandira Saha, Rupali, Pranay Katepogu, Prasad Senthamizh, Tridiv KatiyarAbstractObjectivesThe correlation of XRCC-1 Gene Arg194Trp polymorphism with alcohol and tobacco substance user and with loco-regionally advanced squamous cell cancer of the larynx (LSCC) was assessed in this research study. The result of this research study is described herein.Material and methodsA tertiary hospital-based ob...
Source: Journal of Oral Biology and Craniofacial Research - Category: Dentistry Source Type: research
Oscar-winning actress Patty Duke, star of "The Patty Duke Show" and the Broadway play and film “The Miracle Worker,” died of sepsis from a ruptured intestine on Tuesday. Simple though it may seem, her death announcement is a major milestone for the sepsis awareness movement, said Thomas Heymann, executive director of the Sepsis Alliance. The more people are aware of this condition, Heymann said, the stronger their likelihood of saving their own lives or the lives of their loved ones. "The fact that they said Patty Duke’s cause of death was sepsis is relatively new," Heymann s...
Source: Science - The Huffington Post - Category: Science Source Type: news
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