Scientists home in on reasons behind cancer drug trial disappointment

Scientists have discovered a 'hidden' mechanism which could explain why some cancer therapies which aim to block tumor blood vessel growth are failing cancer trials. The same mechanism could play the role in the bacterial or viral septic shock -- e.g. in Ebola fever -- by destabilizing the blood vessels.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Publication date: Available online 15 December 2018Source: Life SciencesAuthor(s): Zhao Ma, Xuebin Bao, Junbao GuAbstractAimFurowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism.Material and methodsCell Counting Kit-8 (CCK-8) assay was used to determine cell, and TUNEL and Annexin-V/PI staining was used to detect apoptosis and the cell cycle distribution. The expression le...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 December 2018Source: MitochondrionAuthor(s): Justice Afrifa, Tie Zhao, Jingcui YuAbstractThe mitochondria are defined by their unique structure and cellular functions which includes energy production, metabolic regulation, apoptosis, calcium homeostasis, cell proliferation, cell motility and transport as well as free radical generation. Recent advances geared towards enhancing the diagnostic and prognostic value of cancer patients have targeted the circulating mitochondria genome due to its specific and unique characteristics. Circulating mitochondria DNA is known to possess short leng...
Source: Mitochondrion - Category: Biochemistry Source Type: research
Publication date: Available online 16 December 2018Source: The American Journal of SurgeryAuthor(s): Marc Carrier, Alon D. Altman, Normand Blais, Artemis Diamantouros, Deanna McLeod, Uthaman Moodley, Christine Nguyen, Stephanie Young, Frank SchwenterAbstractBackgroundVenous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). Certain abdominopelvic cancer surgeries are associated with a six to 14-fold increased risk of DVT versus surgeries for benign disease, and extended thromboprophylaxis using perioperative LMWHs may further reduce VTE rates over standard duration administration. This r...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 15 December 2018Source: Respiratory Medicine Case ReportsAuthor(s): Keigo Okamoto, Jun HanaokaAbstractCombined subsegmentectomy (CSS) is procedure as diagnostic purpose adding sufficient surgical margin. Compared to other procedure, CSS is not common, with the surgical results also being controversial. We analyzed the patients who had undergoing CSS in the right upper lobe for ground glass opacity (GGO) -dominant nodules. Between April 2011 and March 2017, we experienced 7 cases underwent CSS. In all cases, three subsegments resection and lymph node dissection using Video-Assisted Thoraci...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Authors: Abstract PMID: 30547738 [PubMed - in process]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Tags: Curr Cancer Drug Targets Source Type: research
Authors: Sharif K, Coplan L, Lichtbroun B, Amital H Abstract PMID: 30550010 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
CONCLUSIONS: These observations suggest that BDNF Val66met-SNP has no detectable effect on the peripheral neuropathy that is induced by paclitaxel. The significance of BDNF Val66Met-SNP in pre-existing peripheral neuropathy-related conditions, such as diabetes, should be further investigated. PMID: 30550003 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was suffic...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: similar clinical results and quality of life were achieved after treating elderly patients with colon cancer with a multidisciplinary management approach. PMID: 30545228 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Oscar-winning actress Patty Duke, star of "The Patty Duke Show" and the Broadway play and film “The Miracle Worker,” died of sepsis from a ruptured intestine on Tuesday. Simple though it may seem, her death announcement is a major milestone for the sepsis awareness movement, said Thomas Heymann, executive director of the Sepsis Alliance. The more people are aware of this condition, Heymann said, the stronger their likelihood of saving their own lives or the lives of their loved ones. "The fact that they said Patty Duke’s cause of death was sepsis is relatively new," Heymann s...
Source: Science - The Huffington Post - Category: Science Source Type: news
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