One-step method to generate mice for vaccine research

(Massachusetts General Hospital) To develop vaccines, scientists rely on a variety of animal models, including mice that can produce human antibodies through genetically engineered B cell receptors. These mice, however, often take several years to develop, requiring a complicated process of genetic modification and careful breeding. A Ragon Institute group has developed a one-step method, which uses CRISPR/Cas9 technology, to produce mice with genetically engineered human B cell receptors in just a few weeks.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news