Two polymorphic mutations in promoter region of DNA polymerase β in relatively higher percentage of thymic hyperplasia patients

ConclusionsTwo types of mutations in the promoter region of thePolb gene, ‐168C>A and ‐188_‐187insCGCCC, are associated with thymic hyperplasia and may become a new risk factor for this disease.Key pointsSignificant findings of the studyGenetic mutations in thePolb gene are reported to be associated with different kinds of cancers. However, their relationship with thymic hyperplasia is still unclear.What this study addsFor the first time, we report that two nucleotide mutations in the promoter region of thePolb gene are closely related with thymic hyperplasia after sequencing 59 patients and 60 healthy controls in the Han Chinese population.

Source: Thoracic Cancer - December 13, 2020 Category: Cancer & Oncology Authors: Qingjun Wu, Shan Zhou, Jian Liu, Hongfeng Tong, Yaoguang Sun, Wenxin Tian, Hanbo Yu, Chuan Huang, Donghang Li, Peng Jiao, Chao Ma, Jianping Cai, Dapeng Dai Tags: ORIGINAL ARTICLE Source Type: research