Cigarette Smoke Directly Promotes Pulmonary Arterial Remodeling and Kv7.4 Channel Dysfunction.

CONCLUSIONS: Cigarette smoke directly contributes to pulmonary arterial remodeling through increased cell senescence, as well as vascular tone alterations due to diminished levels and function of the Kv7.4 channel. Strategies targeting these pathways may lead to novel therapies for COPD.
PMID: 33306938 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory and Critical Care Medicine - December 11, 2020 Category: Respiratory Medicine Authors: Sevilla-Montero J, Labrousse-Arias D, Fernández-Pérez C, Fernández-Blanco L, Barreira B, Mondéjar-Parreño G, Alfaro-Arnedo E, López IP, Pérez-Rial S, Peces-Barba G, Pichel JG, Peinado VI, Cogolludo Á, Calzada MJ Tags: Am J Respir Crit Care Med Source Type: research