Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and NETs.

Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and NETs. Thromb Haemost. 2020 Dec 11;: Authors: Rangaswamy C, Englert H, Deppermann C, Renné T Abstract Neutrophils extracellular traps (NETs) and polyphosphates (polyP) have been recognized as procoagulant polyanions. The review summarizes the activities and regulation of two procoagulant mediators and compares their functions. NETs are composed of DNA and share a phosphate backbone with polyP that is built of phosphate units linked by high energy phospho-anhydride bonds. Both NETs and polyP form insoluble particulate surfaces composed of a DNA/histone meshwork or Ca2+-rich nanoparticles, respectively. The polyanions modulate coagulation involving an array of mechanisms and trigger thrombosis via activation of the factor XII (FXII)-driven procoagulant and proinflammatory contact pathway. This review outlines the current knowledge on NETs and polyP with respect to their procoagulant and prothrombotic nature, strategies for interference of their activities in circulation, as well as the crosstalk between these two molecules. A better understanding of these underlying, cellular mechanisms will shed light on the therapeutic potential of targeting NETs and polyP in coagulation and thrombosis. PMID: 33307564 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research