Comparison of static and dynamic models of maternal immunization to prevent infant pertussis in Brazil.

CONCLUSIONS: Static models may serve to explore an intervention's cost-effectiveness against infectious disease: the direction and principal drivers of change were the same in both models. When, however, an intervention too small to have significant herd immunity effects itself, such as maternal aP immunization, takes place against a background of vaccination in the rest of the population, a dynamic model is crucial to accurate estimates of cost-effectiveness. This finding is particularly important in the context of widely varying routine infant vaccination rates globally. CLINICAL TRIAL REGISTRY: Clinical Trial registry name and registration number: Not applicable. PMID: 33303183 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/33303183?dopt=Abstract

Source: Vaccine - December 13, 2020 Category: Allergy & Immunology Authors: Russell LB, Kim SY, Toscano C, Cosgriff B, Minamisava R, Lucia Andrade A, Sanderson C, Sinha A Tags: Vaccine Source Type: research