Efficacy of decitabine in malignant meningioma cells: relation to promoter demethylation of distinct tumor suppressor and oncogenes and independence from TERT.

CONCLUSIONS: Decitabine decreases proliferation and viability in high-grade but not in benign meningioma cell lines. The effects of decitabine are TERT independent but related to DNA methylation changes of promoters of distinct tumor suppressor genes and oncogenes. PMID: 33307532 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33307532?dopt=Abstract

Source: Journal of Neurosurgery - December 11, 2020 Category: Neurosurgery Authors: Stögbauer L, Thomas C, Wagner A, Warneke N, Bunk EC, Grauer O, Canisius J, Paulus W, Stummer W, Senner V, Brokinkel B Tags: J Neurosurg Source Type: research