Connecting the dots: combined control of endocytic recycling and degradation.

Connecting the dots: combined control of endocytic recycling and degradation.
Biochem Soc Trans. 2020 Dec 10;:
Authors: MacDonald E, Savage B, Zech T
Abstract
Endocytosis is an essential process where proteins and lipids are internalised from the plasma membrane in membrane-bound carriers, such as clathrin-coated vesicles. Once internalised into the cell these vesicles fuse with the endocytic network where their contents are sorted towards degradation in the lysosome or recycling to their origin. Initially, it was thought that cargo recycling is a passive process, but in recent years the identification and characterisation of specialised recycling complexes has established a hitherto unthought-of level of complexity that actively opposes degradation. This review will summarise recent developments regarding the composition and regulation of the recycling machineries and their relationship with the degradative pathways of the endosome.
PMID: 33300959 [PubMed - as supplied by publisher]

Source: Biochemical Society Transactions - December 10, 2020 Category: Biochemistry Authors: MacDonald E, Savage B, Zech T Tags: Biochem Soc Trans Source Type: research