Soybean lectin induces autophagy through P2RX7 dependent activation of NF- κB-ROS pathway to kill intracellular mycobacteria.

Conclusion Taken together, these results conclude that SBL induced autophagy exerts an anti-mycobacterial effect in P2RX7-NF-κB dependent manner through the generation of ROS. General significance This study has provided a novel anti-mycobacterial role of SBL, which may play an important role in devising new therapeutic interventions.
PMID: 33301752 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - December 7, 2020 Category: Toxicology Authors: Mishra A, Behura A, Kumar A, Ghosh A, Naik L, Mawatwal S, Mohanty SS, Mishra A, Saha S, Bhutia SK, Singh R, Dhiman R Tags: Toxicol Appl Pharmacol Source Type: research