Polymorphism in the catalytic subunit of the PI3K γ gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy.

In conclusion, the presence of the T allele at single or double doses may differentiate the cardiac from other clinical manifestations of Chagas disease. This finding should help in further studies to evaluate the mechanisms underlying the differential association of PIK3CG in Chagas disease.
PMID: 33301989 [PubMed - as supplied by publisher]

Source: Infection, Genetics and Evolution - December 7, 2020 Category: Genetics & Stem Cells Authors: Silva MC, da Silva Medina T, Fuzo CA, Dias FC, Freitas-Castro F, Fukutani KF, Donadi EA, Cunha-Neto E, Cunha TM, Silva JS Tags: Infect Genet Evol Source Type: research