Postnatal metformin treatment alters rat Sertoli cell proliferation and daily sperm production

Discussion and conclusionThese results suggest that metformin treatment may lead to a decrease in Sertoli cell proliferation, a concomitant altered expression of cell cycle regulators and ultimately, a reduction in daily sperm production in adult animals.

Source: Andrology - December 11, 2020 Category: Urology & Nephrology Authors: Gustavo Marcelo Rindone, Agostina Gorga, Eliana Herminia Pellizzari, Mar ía del Carmen Camberos, María Noel Galardo, Vanina Gabriela Da Ros, Mariano Gabriel Buffone, Silvina Beatriz Meroni, María Fernanda Riera Tags: ORIGINAL ARTICLE Source Type: research