Intramuscular oxytocin versus Syntometrine versus carbetocin for prevention of primary postpartum haemorrhage after vaginal birth: a randomised double-blinded clinical trial of effectiveness, side effects and quality of life.

CONCLUSIONS: Non inferiority of carbetocin to Syntometrine was not shown. Carbetocin is not significantly different to oxytocin for use of additional uterotonics. Use of Syntometrine reduced use of additional uterotonics and need for non-drug PPH treatments compared with oxytocin. Increased maternal side effects are a disadvantage of Syntometrine.
PMID: 33300296 [PubMed - as supplied by publisher]

Source: BJOG : An International Journal of Obstetrics and Gynaecology - December 10, 2020 Category: OBGYN Authors: van der Nelson H, O'Brien S, Burnard S, Mayer M, Alvarez M, Knowlden J, Winter C, Dailami N, Marques E, Burden C, Siassakos D, Draycott T Tags: BJOG Source Type: research