Differential associations between a priori diet quality scores and markers of cardiovascular health in women: cross sectional analyses from Twins UK.

Differential associations between a priori diet quality scores and markers of cardiovascular health in women: cross sectional analyses from Twins UK. Br J Nutr. 2020 Dec 10;:1-26 Authors: Mompeo O, Berry SE, Spector TD, Menni C, Mangino M, Gibson R Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide and, after dementia, is the second biggest cause of death for women. In England it accounts for 1 in 4 of all deaths. Lifestyle modifications represent the primary route to both reduce CVD risk factors and prevent CVD outcomes. Diet constitutes one of the key modifiable risk factors in the aetiology of CVD. We investigated the relationship between nine main dietary indices and a comprehensive range of CVD risk factors in 2,590 women from TwinsUK. After adjustment for multiple testing, we found that the DASH diet was inversely correlated with some of the most common CVD risk factors (BMI, visceral fat, triglycerides, insulin HOMA2-IR and ASCVD risk) with PFDR ranging from 6.28*10-7 to 5.63*10-4. Similar association patterns were detected across most of the dietary indices analysed. In our post hoc investigation, to determine if any specific food groups were driving associations between the DASH score and markers of cardiometabolic risk, we found that increased BMI, VF, HOMA2-IR, ASCVD risk, insulin and triglyceride levels were directly correlated to red meat consumption (PFDR ranging from 4.65*10-9 to 7.98*10-3) a...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research