Manno-oligosaccharide attenuates inflammation and intestinal epithelium injury in weaned pigs upon Enterotoxigenic Escherichia Coli K88 challenge.

Manno-oligosaccharide attenuates inflammation and intestinal epithelium injury in weaned pigs upon Enterotoxigenic Escherichia Coli K88 challenge. Br J Nutr. 2020 Dec 10;:1-37 Authors: Yu E, Chen D, Yu B, Huang Z, Mao X, Zheng P, Luo Y, Heng Y, Yu J, Luo J, Yan H, He J Abstract To explore the effect of mannan-oligosaccharide (MOS) on intestinal health in weaned pigs upon Enterotoxigenic Escherichia coli K88 (ETEC) challenge, thirty-two male weaned pigs were randomly assigned into four groups. Pigs fed with a basal diet or basal diet containing MOS (0.6 g/kg) were orally infused with ETEC or culture medium. Results showed that MOS significantly elevated the digestibility of crude protein (CP) and gross energy (GE) in both ETEC-challenged and non-challenged pigs (P < 0.05). MOS also elevated serum concentrations of immunoglobulin (Ig) A and IgM (P < 0.05), but decreased serum concentrations of tumor necrosis factor (TNF)-α, IL-1β, and IL-6 (P < 0.05) in ETEC-challenged pigs. Interestingly, MOS increased villus height and the ratio of villus height to crypt depth (V/C) in duodenum and ileum (P < 0.05). MOS also increased duodenal sucrase and ileal lactase activity in ETEC-challenged pigs (P < 0.05). MOS decreased the abundance of Escherichia coli, but increased the abundance of Lactobacillus, Bifidobacterium, and Bacillus in cecum (P < 0.05). Importantly, MOS not only elevated the expression levels of zonula occludin...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research