Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the Milieu Int érieur population of healthy adults.

Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the Milieu Intérieur population of healthy adults. Br J Nutr. 2020 Dec 10;:1-29 Authors: Partula V, Deschasaux-Tanguy M, Mondot S, Victor-Bala A, Bouchemal N, Lecuyer L, Bobin-Dubigeon C, Torres MJ, Kesse-Guyot E, Charbit B, Patin E, Assmann KE, Latino-Martel P, Julia C, Galan P, Hercberg S, Quintana-Murci L, Albert ML, Duffy D, Lantz O, Savarin P, Nawfal Triba M, Touvier M, Milieu Intérieur Consortium Abstract Host-microbial co-metabolism products are being increasingly recognized to play important roles in physiological processes. However, studies undertaking a comprehensive approach to consider host-microbial metabolic relationships remain scarce. Metabolomic analysis yielding detailed information regarding metabolites found in a given biological compartment holds promise for such an approach. This work aimed to explore the associations between host plasma metabolomic signatures and gut microbiota composition in healthy adults of the Milieu Intérieur study. For 846 subjects, gut microbiota composition was profiled through sequencing of the 16S rRNA gene in stools. Metabolomic signatures were generated through proton nuclear magnetic resonance analysis of plasma. The associations between metabolomic variables and α- and β-diversity indexes and relative taxa abundances were tested using multi-adjusted partial Spearman correlations, P...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research