The Use of Polyethylene Glycol in the Pediatric Population (R01)

Funding Opportunity RFA-FD-14-002 from the NIH Guide for Grants and Contracts. The purpose of the proposed study is to better understand the extent of pediatric absorption of low molecular weight species that may be found in PEG 3350 products (e.g., ethylene and diethylene glycol). PEG 3350 products are used in the treatment of constipation. These low molecular weight species may be absorbed by children taking PEG 3350 products, potentially leading to adverse events. This is an important first step needed to begin to understand if PEG 3350 use contributes to adverse events in children due to the absorption of these species.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Conditions:   Opioid-induced Constipation;   Cancer;   Cancer Pain Intervention:   Other: Treatment algorithm for OIC Sponsors:   Royal Surrey County Hospital NHS Foundation Trust;   Kyowa Hakko Kirin UK, Ltd. Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Celiac disease (CD), triggered by the ingestion of gluten, occurs in people genetically predisposed to develop the chronic autoimmune condition. During the past few decades, doctors have learned much about how the disease develops, including genetic and other risk factors. However, results from studies on whether people with CD have an increased risk of premature death linked to the condition have been mixed. A recent study shows a small but statistically significant increased mortality rate. Celiac disease can affect the entire body Until recently, CD was considered a mainly pediatric gastrointestinal disorder, associated...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Autoimmune diseases Source Type: blogs
Conclusions: The commonness of undesirable experiences attributed to daily ingestion of 60 mg iron and 0.4 mg folic acid and their deterrence to longer supplementation durations suggest the need for considering a weekly intermittent regimen for some antenatal women in such set-ups. Our study demonstrated that potentially, more counselling on nausea as a side effect might be critical in advancing iron-folate supplementation compliance. PMID: 32455019 [PubMed - as supplied by publisher]
Source: Journal of Pregnancy - Category: OBGYN Tags: J Pregnancy Source Type: research
Authors: Ciriza de Los Ríos C, Aparicio Cabezudo M, Zatarain Vallés A, Rey Díaz-Rubio E Abstract Obstructed defecation syndrome produces constipation with anal blockage and a feeling of incomplete evacuation, due to either anatomic and functional causes. This is a complex and multifactorial entity due to diverse etiological factors that may coexist in many patients. Therefore, a diagnostic approach requires structural and functional assessment. The concordance between findings of diagnostic tests is suboptimal, thus an individualized analysis is mandatory in each patient. Therapeutic strategies...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Conclusion Transanal Soave PT with or without assistance was effective in resolving different problems after initial PT, while soiling was the most common postoperative problem, especially patients with anastomotic complication. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: European Journal of Pediatric Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research
ConclusionThis study reviews the largest cohort of patients with BBD in DS. It is common with serious consequences requiring operative intervention. Usual interventions are unreliable due to poor compliance. Early identification and management protect the renal tract. Regular screening for urogenital anomalies in DS is currently not performed. We recommend a thorough history of bladder function in DS patients to identify these cases early.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
CONCLUSIONS: Hepatoblastoma is the most common primary liver tumor in children and has an increased incidence in children with a history of prematurity and very low birth weight. Providers who frequently care for the very low birth weight and premature children with CP should be aware of this correlation and include hepatoblastoma in the differential when managing patients with suddenly worsening constipation or abdominal distension. Pediatric physiatrists and other providers for these patients could be a source of referrals and diagnosis leading to timely treatment. PMID: 32444576 [PubMed - as supplied by publisher]
Source: Journal of Pediatric Rehabilitation Medicine - Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research
AbstractChronic constipation is one of the five most common symptoms seen by gastroenterologist. In the absence of alarm symptoms, a confident symptom-based diagnosis can often be made using the Rome criteria. Three different subtypes have been identified to date: normal transit constipation, defaecatory disorders and slow transit constipation. Differentiation between these subtypes can be made through functional testing using tests such as anorectal manometry with balloon expulsion and a radio-opaque marker test. In general, patients are initially advised to increase their fluid and fibre intake. When these general lifest...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
People who sleep more or less than average report significantly more constipation than those who sleep 7 to 8 hours a night, new research shows.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Authors: Alemrajabi M, Darabi B, Banivaheb B, Hemmati N, Jahanian S, Moradi M Abstract Background: Obstructive defecation syndrome (ODS) affects quality of life of patients to a great extent by disturbing defecation. Laparoscopic ventral mesh rectopexy (LVMR) has gained much attention in the recent years. Common synthetic used meshes have a risk of erosion for adjacent pelvic organs leading to some complications. The aim of this study was to assess the outcomes of LVMR using polyvinylidene fluoride (PVDF) mesh in patients with ODS for the first time.Methods and Materials: In this experimental study, patients with a...
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
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