Anti-Leishmania amazonensis activity of the terpenoid fraction from Eugenia pruniformis leaves.
This study aimed to evaluate the anti-Leishmania amazonensis activity of the terpenoid fraction of Eugenia pruniformis leaves (TF-EpL). TF-EpL was active against the promastigote and intracellular amastigote forms of L. amazonensis with IC50(24h) value of 43.60μg/mL and 44.77μg/mL, respectively. TF-EpL altered the cell cycle of the parasite, increasing 2.32-fold the cells in the Sub-G0/G1 phase. TF-EpL also changed the ΔΨm and increased ROS and the number of annexin-V-PI positive promastigotes, which suggests incidental death. β-sitosterol, ursolic acid, corosolic acid and asiatic acid were isolated from TF-EpL. The results showed the antileishmanial activity of E. pruniformis terpenoids and its potential for further studies as a source of new drugs for leishmaniasis.
PMID: 33295583 [PubMed - in process]
Source: An Acad Bras Cienc - Category: Science Authors: Albuquerque RDDG, Oliveira AP, Ferreira C, Passos CLA, Fialho E, Soares DC, Amaral VF, Bezerra GB, Esteves RS, Santos MG, Albert ALM, Rocha L Tags: An Acad Bras Cienc Source Type: research
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