Purines and Pyrimidines: Metabolism, Function and Potential as therapeutic options in neurodegenerative diseases.
Purines and Pyrimidines: Metabolism, Function and Potential as therapeutic options in neurodegenerative diseases.
Curr Protein Pept Sci. 2020 Dec 08;:
Authors: Kundu D, Dubey VK
Abstract
Various neurodegenerative disorders have molecular origin but some common molecular mechanisms. In the current scenario, there are very few treatment regimens present for advanced neurodegenerative diseases. In this context, there is an urgent need for alternate options in the form of natural compounds with an ameliorating effect on patients. There have been individual scattered experiments trying to identify potential values of various intracellular metabolites. Purines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical reactions, have been long sought as crucial candidates for the same, but there are still many questions that go unanswered. Some critical functions of these molecules associated with neuromodulation activities have been identified. They are also known to play a role in foetal neurodevelopment, but there is a lacuna in understanding their mechanisms. In this review, we have tried to assemble and identify the importance of purines and pyrimidines, connecting them with the prevalence of neurodegenerative diseases. The leading cause of this class of diseases is protein misfolding and the formation of amyloids. A direct correlation between loss of balance in cellular homeostasis and amyloidosis is...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Kundu D, Dubey VK Tags: Curr Protein Pept Sci Source Type: research