SupErbB monocytes? Innate immune cells help the heart adapt

Acute immune cell recruitment and activation occurs in response to virtually every tissue stress or injury. In the heart, ischemia is the prototypical paradigm in which myeloid cells such as monocytes, macrophages or neutrophils modulate acute wound healing or prolonged inflammation and scarring. However, a growing body of literature has demonstrated diverse roles for myeloid cells in non-ischemic cardiomyopathies, in metabolic syndromes, and in maintenance of cardiac homeostasis. Moreover, the intricacies of myeloid cells have expanded and considerable phenotypic diversity even among a single cell type is now well recognized [1].
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Editorial Source Type: research
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