Effect of a moderate dose of fructose in solid foods on triglyceride, glucose and uric acid before and after a one-month moderate sugar feeding period.

Effect of a moderate dose of fructose in solid foods on triglyceride, glucose and uric acid before and after a one-month moderate sugar feeding period. Br J Nutr. 2020 Dec 09;:1-16 Authors: Clifton PM, Keogh JB Abstract There are few data on the effects on triglyceride, glucose and uric acid of chronic consumption of a moderate dose fructose in solid foods. Twenty-eight participants with prediabetes and/or obesity and overweight commenced the study (BMI 32.3 kg/m2, age 44.7 years, fasting glucose 5.3 (SD 0.89) mmol/L and 2-hour glucose 6.6 (SD 1.8) mmol/L). Twenty-four men and women who completed the study consumed, in random order, two acute test meals of muffins sweetened with either fructose or sucrose. This was followed by 4 weeks chronic consumption of 42g/day of either fructose or sucrose in low fat muffins after which the 2 meal tests were repeated. The sugar type in the chronic feeding period was also randomised. Fasting triglyceride increased after chronic consumption of fructose by 0.31±0.37 mmol/L compared with sucrose in those participants with IFG/IGT (P=0.004). Total cholesterol (0.33 mmol/L), LDL cholesterol (0. 24 mmol/l) and HDL cholesterol (0.08 mmol/L) increased significantly over the 1 month feeding period with no differences between muffin types. Fasting glucose was not different after 1 month of muffin consumption. Uric acid response was not different between the two sugar types either baseline or 1 month and t...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research