Importance of Zebrafish as an efficient research model for the screening of novel therapeutics in neurological disorders.

Importance of Zebrafish as an efficient research model for the screening of novel therapeutics in neurological disorders. CNS Neurol Disord Drug Targets. 2020 Dec 07;: Authors: Saluja D, Jhanji R, Kaushal S, Verma B, Sharma N, Singh R, Agrawal S, Yadav M, Kumar A, Singh C, Singh A Abstract In the previous years of research, the use of animal model becomes very common for the screening of novel drugs. Animal model represents the complex problems of humans into simplest forms which can be extended further to include the experimental procedure. The most successful models in neuroscience, rats and mice, undoubtedly considered as one of the best models to understand the psychology of mammalian brain and its associated functions involved in various behavioral repertoire. Moreover, recently researchers in behavioral neuroscience are focusing more on the use of aquatic animals especially fish as model species due to their simplicity, and cost effectiveness. Zebrafish (Danio rerio) is a tropical fish from minnow family a genetic structure surprisingly 84 % similar to humans. It is gaining popularity as a model to study the mechanism in behavioral neuropharmacology. Moreover, Zebrafish is having numerous advantages over other rodent models like ease in maintenance due to their small size; breeding power is more, transparency of embryos, overall reduced cost of experimentation and many more. Nowadays, it is considered as an ideal model to study...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research