Differences in the immune response of the non-metastatic axillary lymph nodes between triple-negative and luminal A breast cancer surrogate subtypes

Breast cancer (BC) comprises four immunohistochemical surrogate subtypes, of which triple-negative breast cancer (TNBC) has the highest risk of mortality. Axillary lymph nodes (ALNs) are the regions where BC cells first establish before distant metastasis, and the presence of tumor cells in the ALN gives rise to an immune tolerance profile that contrasts with that of the non-metastatic ALN (ALN-). However, few studies have compared the immune components of the ALNs- in BC subtypes. The present study aimed to determine whether differences between immune populations in the primary tumor and ALNs- were associated with the luminal A or TNBC subtype.

Source: American Journal of Pathology - December 9, 2020 Category: Pathology Authors: Carlos L ópez, Albert Gibert-Ramos, Ramón Bosch, Anna Korzynska, Marcial García-Rojo, Gloria Bueno, Joan Francesc García-Fontgivell, Salomé Martínez González, Laia Fontoura, Andrea Gras Navarro, Esther Sauras Colón, Júlia Casanova Ribes, Lukasz R Tags: Regular article Source Type: research