Effect of Treatment with Inactive Vitamin D on the Intracranial Blood Flow in Patients with Chronic Obstructive Pulmonary Disease

AbstractThe goal of the work was to assess the dynamics of ultrasound parameters of renal blood flow in patients with chronic obstructive pulmonary disease (COPD) and the initial stages of chronic kidney disease (CKD) upon treatment with inactive vitamin D. The study included 264 patients with COPD the second to fourth degrees of severity in combination with CKD of stages I –II: 135 patients in the main group and 129 patients in the control group. Each group was divided into four subgroups according to the FEV1 and vitamin D levels. Native vitamin D was prescribed according to a scheme allowing the maintenance of vitamin D at a level of>34.3 ng/mL during the year for the main group and in accordance with the recommendations of the Russian Association of Endocrinologists for the control group. An ultrasound of the kidneys with calculation of the resistance index (RI) and albuminuria level were carried out for all patients upon inclusion in the study and after its completion. A decrease in the severity of albuminuria from A3 to A2 was revealed in 24.1% (16), and an increase in the glomerular filtration rate (GFR) was observed in 42.9% (58) patients of all patients in the main group. A statistically significant decrease in the renal artery resistance index was recorded in the group of patients with moderate COPD (GOLD 2) and vitamin-D deficiency in the main group (p< 0.05). The maintenance of vitamin-D levels more than 34.3 ng/mL over 12 months in patients with COPD in c...
Source: Advances in Gerontology - Category: Geriatrics Source Type: research