Human and Veterinary Vaccines for Lyme Disease.

Human and Veterinary Vaccines for Lyme Disease. Curr Issues Mol Biol. 2020 Dec 08;42:191-222 Authors: O'Bier NS, Hatke AL, Camire AC, Marconi RT Abstract Lyme disease (LD) is an emerging zoonotic infection that is increasing in incidence in North America, Europe, and Asia. With the development of safe and efficacious vaccines, LD can potentially be prevented. Vaccination offers a cost-effective and safe approach for decreasing the risk of infection. While LD vaccines have been widely used in veterinary medicine, they are not available as a preventive tool for humans. Central to the development of effective vaccines is an understanding of the enzootic cycle of LD, differential gene expression of Borrelia burgdorferi in response to environmental variables, and the genetic and antigenic diversity of the unique bacteria that cause this debilitating disease. Here we review these areas as they pertain to past and present efforts to develop human, veterinary, and reservoir targeting LD vaccines. In addition, we offer a brief overview of additional preventative measures that should employed in conjunction with vaccination. PMID: 33289681 [PubMed - as supplied by publisher]
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Tags: Curr Issues Mol Biol Source Type: research