Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF- κB activation.

In conclusion, the results show that AS-IV has significant protective effects against retinal iron overload toxicity and suggest that iron regulation and the inhibition of MAPKs and NF-κB activation might be mechanisms underlying the effects of AS-IV. PMID: 33285147 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33285147?dopt=Abstract

Source: Toxicology and Applied Pharmacology - December 4, 2020 Category: Toxicology Authors: Song Q, Zhao Y, Yang Y, Han X, Duan J Tags: Toxicol Appl Pharmacol Source Type: research