Semaphorin 4A antibody alleviates arsenic-induced hepatotoxicity in mice via inhibition of AKT2/NF- κB inflammatory signaling.

In conclusion, the anti-Sema 4A antibody antagonizes arsenic-induced hepatotoxicity in mice and may be involved in the inhibitions of AKT2/NF-κB and NLRP3 inflammatory signaling mediated synergistically by Sema 4A or Sema 3A and their receptor NRP-1.
PMID: 33290778 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - December 5, 2020 Category: Toxicology Authors: Yang Y, Wang Q, Wang W, Wei S, Zeng Q, Zhang A Tags: Toxicol Appl Pharmacol Source Type: research