Myeloid-Derived IL-33 Limits the Severity of Dextran Sulfate Sodium –Induced Colitis

IL-33 is an IL-1 family cytokine that signals through its cognate receptor, ST2, to regulate inflammation. It is controversial whether IL-33 serves a pathogenic or protective role during inflammatory bowel disease. Herein, two different strains of cell-specific conditionally deficient mice were used to compare the role of myeloid- versus intestinal epithelial cell –derived IL-33 during dextran sodium sulfate–induced colitis. Data show that loss of CD11c-restricted IL-33 exacerbated tissue pathology, coinciding with increased tissue Il6 levels and loss of intestinal Foxp3+ regulatory T cells, but surprisingly, the lack of intestinal epithelial cell–deriv ed IL-33 had no impact on disease severity or tissue recovery.

Source: American Journal of Pathology - November 23, 2020 Category: Pathology Authors: Li-Yin Hung, Christopher F. Pastore, Bonnie Douglas, De ’Broski R. Herbert Tags: Short communication Source Type: research