High serum neurofilament associates with diffuse white matter damage in MS

Conclusions
Our findings suggest that elevated serum NfL in MS results from neuroaxonal damage both within the NAWM and focal T2 lesions. This pathologic heterogeneity ought to be taken into account when interpreting NfL findings at the individual patient level.

Source: Neurology Neuroimmunology and Neuroinflammation - December 8, 2020 Category: Neurology Authors: Saraste, M., Bezukladova, S., Matilainen, M., Tuisku, J., Rissanen, E., Sucksdorff, M., Laaksonen, S., Vuorimaa, A., Kuhle, J., Leppert, D., Airas, L. Tags: DWI, Multiple sclerosis Article Source Type: research