Ubiquitin-like protein FAT10 suppresses SIRT1-mediated autophagy to protect against ischemic myocardial injury

Autophagy plays a deleterious role in ischemic myocardial injury. The deacetylase SIRT1 is a well-established regulator of autophagy that can be modified by the ubiquitin-like protein SUMO1. Our previous work demonstrated that another ubiquitin-like protein, FAT10, exerts cardioprotective effects against myocardial ischemia by stabilizing the caveolin-3 protein; however, the effects of FAT10 on autophagy through SIRT1 are unclear. Here, we constructed a Fat10-knockout rat model to evaluate the role of FAT10 in autophagy.

Source: Journal of Molecular and Cellular Cardiology - December 8, 2020 Category: Cytology Authors: Rong Wan, Ping Yuan, Linjuan Guo, Jianghua Shao, Xiao Liu, Wei Lai, Qiling Kong, Leifeng Chen, Jin Ge, Zhenyan Xu, Jinyan Xie, Yang Shen, Jianping Hu, Qiongqiong Zhou, Jianhua Yu, Zhenhong Jiang, Xinghua Jiang, Kui Hong Source Type: research