Exercise Intolerance in Kidney Diseases: Physiological Contributors and Therapeutic Strategies.

Exercise Intolerance in Kidney Diseases: Physiological Contributors and Therapeutic Strategies. Am J Physiol Renal Physiol. 2020 Dec 07;: Authors: Kirkman DL, Bohmke N, Carbone S, Garten RS, Rodriguez-Miguelez P, Franco RL, Kidd JM, Abbate A Abstract Exertional fatigue, defined as the overwhelming and debilitating sense of sustained exhaustion that impacts the ability to perform activities of daily living, is highly prevalent in chronic kidney disease (CKD) and end stage renal disease (ESRD). Subjective reports of exertional fatigue are paralleled by objective measurements of exercise intolerance throughout the spectrum of the disease. The prevalence of exercise intolerance is clinically noteworthy as it leads to increased frailty, worsened quality of life and an increased risk of mortality. The physiological underpinnings of exercise intolerance are multifaceted and still not fully understood. This review aims to provide a comprehensive outline of the potential physiological contributors, both central and peripheral, to kidney disease related exercise intolerance and highlight current and prospective interventions to target this symptom. In this review the kidney disease-related metabolic derangements, cardiac and pulmonary dysfunction, altered physiologic responses to oxygen consumption, vascular derangements and sarcopenia are discussed in the context of exercise intolerance. Lifestyle interventions to improve exertional fatigue, ...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research