The degeneration of upper and lower motor neuron from the perspective of clinical neurological examination and MRI-electromyography manifold detection in amyotrophic lateral sclerosis

Objective The aim of this study was to explore the upper motor neurons (UMN) and lower motor neurons (LMN) degeneration in amyotrophic lateral sclerosis (ALS) from the perspective of the clinical neurological examination and MRI-electromyography manifold detection, respectively. Methods The clinical data, cortical thickness of corresponding areas in different body regions in MRI and electromyography data were collected from 108 classical ALS patients. Results The kappa value of UMN and LMN involvement signs in the bulbar region (0.31) was higher than that of the left upper limb (−0.13), right upper limb (−0.27), left lower limb (−0.05) and right lower limb (−0.08). The cortical thickness in the positive LMN damage group was thinner than that of the negative LMN damage group in the left head–face area (P 
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research