Cytokine Polymorphisms and Predisposition to Diabetic Nephropathy: A Meta-Analysis

Conclusion: The meta-analysis results demonstrated thatTNF- α–238 G/A,TNF- α–308 G/A,TNF- α–1031 C/T,IL-1A−889 C/T,IL-1B−511 C/TandIL-18–137 G/Cpolymorphisms might influence predisposition to DN in the overall pooled population. Moreover,TNF- α –308 G/A,IL-1B−511 C/T andIL-18–137 G/C polymorphisms might influence predisposition to DN in Asians, whereas theIL-1B−511 C/T polymorphism might also influence predisposition to DN in Caucasians.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research