Mitochondrial Ca2+, redox environment and ROS emission in heart failure: Two sides of the same coin?

Heart failure (HF) is a progressive, debilitating condition characterized, in part, by altered ionic equilibria, increased ROS production and impaired cellular energy metabolism, contributing to variable profiles of systolic and diastolic dysfunction with significant functional limitations and risk of premature death. We summarize current knowledge concerning changes of intracellular Na+ and Ca2+ control mechanisms during the disease progression and their consequences on mitochondrial Ca2+ homeostasis and the shift in redox balance.

Source: Journal of Molecular and Cellular Cardiology - December 7, 2020 Category: Cytology Authors: Sonia Cortassa, Magdalena Juhaszova, Miguel A. Aon, Dmitry B. Zorov, Steven J. Sollott Source Type: research