Enhancer II-targeted dsRNA decreases GDNF expression via histone H3K9 trimethylation to inhibit glioblastoma progression.

CONCLUSIONS: Our results demonstrate that a promoter-targeted dsRNA can silence or promote gene transcription depending on its targeted site in different cis-acting elements in the gene promoter. Targeted inhibition of GDNF by enhancer II-targeted dsRNA may be explored as a novel treatment for GBM. PMID: 33278485 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33278485?dopt=Abstract

Source: Brain Research Bulletin - December 2, 2020 Category: Neurology Authors: Zhang B, Han X, Gao Q, Liu J, Li S, Zha W, Wang X, Guo X, Gao D Tags: Brain Res Bull Source Type: research