Recruitment strategies and design considerations in a trial of resistance training to prevent dose-limiting toxicities in colon cancer patients undergoing chemotherapy
Low muscle is associated with an increased risk of chemotherapy-related dose limiting toxicities (DLT) in cancer patients. Resistance training (RT) improves muscle mass; however, the effects of RT on preventing DLTs and dose reductions in colon cancer patients has not been investigated.FOcus on Reducing dose-limiting toxicities in Colon cancer with resistance Exercise (FORCE) is a multicenter, randomized clinical trial examining the effects of RT on relative dose intensity (RDI; primary outcome) and moderate and severe chemotoxicities (primary outcome) in non-metastatic colon cancer patients receiving adjuvant chemotherapy.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Bette J. Caan, Jeffrey A. Meyerhardt, Justin C. Brown, Kristin L. Campbell, Elizabeth M. Cespedes Feliciano, Catherine Lee, Michelle C. Ross, Sara Quinney, Charles Quesenberry, Barbara Sternfeld, Kathryn H. Schmitz Source Type: research
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