Modulatory effect of rapamycin and tacrolimus on monocyte-derived dendritic cells phenotype and function.

CONCLUSION: Rapa-DCs exhibit an incomplete phenotypic tolerogenic profile. To our knowledge this is the first paper showing a reduction of expression of pro-tolerogenic enzyme IDO in DCs. Tacrolimus does not change the phenotypical or functional characteristics of moDCs.
PMID: 33278711 [PubMed - as supplied by publisher]

Source: Immunobiology - November 23, 2020 Category: Allergy & Immunology Authors: Dahlqvist G, Renaud S, Barjon C, Lefebvre A, Aoudjehane L, Horsmans Y, Delhem N, Conti F Tags: Immunobiology Source Type: research