Potential Utility of Cardio-Renal Biomarkers For Prediction and Prognostication of Worsening Renal Function in Acute Heart Failure

Acute kidney dysfunction is frequently observed in patients with acute heart failure (AHF). This has been termed worsening renal function (WRF), usually defined as a deterioration in kidney function reflected by increasing creatinine and decreasing glomerular filtration rate (GFR) [1-5]. WRF has been variably associated with worse, neutral or even improved outcomes [1-5]. This variability is likely a product of different pathophysiologic processes driving alterations in renal function and potentially depends on whether acute tubular injury (ATI) is occurring [5].

Source: Journal of Cardiac Failure - December 5, 2020 Category: Cardiology Authors: Yu Horiuchi, Nicholas Wettersten, Dirk J. van Veldhuisen, Christian Mueller, Gerasimos Filippatos, Richard Nowak, Christopher Hogan, Michael C. Kontos, Chad M. Cannon, Gerhard A. M üeller, Robert Birkhahn, Pam Taub, Gary M. Vilke, Olga Barnett, Kenneth M Source Type: research