Radiobiological effects of the interruption time with Monte Carlo Simulation on multiple fields in photon beams.

CONCLUSION: The ~10-min interruption of 6-MV photon beams did not significantly impact the radiobiological effectiveness, since the RBE decrease was <3%. Nevertheless, the RBE's effect on tumor cells was decreased about 30% by increasing the 60 min interruption time at 8 Gy with four-field irradiation. It is thus necessary to make the interruption time as short as possible.
PMID: 33270984 [PubMed - as supplied by publisher]

Source: Clinical Lung Cancer - December 3, 2020 Category: Cancer & Oncology Authors: Nakano H, Kawahara D, Tanabe S, Utsunomiya S, Takizawa T, Sakai M, Saito H, Ohta A, Kaidu M, Ishikawa H Tags: J Appl Clin Med Phys Source Type: research