Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020

A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producingKlebsiella pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020, ST147 NDM-9-producingK. pneumoniae were detected at the University Hospital of Pisa, Tuscany, in two critically ill patients; one developed bacteraemia. Genomic and phylogenetic analyses suggest relatedness of 2018–2019 and 2020 strains, with a change from NDM-1 to NDM-9 in the latter and evolution by colistin, tigecycline and fosfomycin resistance acquisition.

Source: Eurosurveillance - December 3, 2020 Category: Infectious Diseases Authors: Marco Falcone, Cesira Giordano, Simona Barnini, Giusy Tiseo, Alessandro Leonildi, Paolo Malacarne, Francesco Menichetti and Alessandra Carattoli Source Type: research