Penicillin and cephalosporin cross-reactivity: role of side chain and synthetic cefadroxil epitopes

ConclusionsCross-reactivity with CX in AX allergic patients is 35%, being ST not enough for prediction. R1, although critical for recognition, is not the unique factor. The synthetic determinants of CX,  1-(HOPhG-Ser-Bu) and  2-(pyrazinone) are promising tools for determining in vitro cross-reactivity to CX in AX allergic patients.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research