Comparison of adequacy between transbronchial lung cryobiopsy samples and endobronchial ultrasound ‐guided transbronchial needle aspiration samples for next‐generation sequencing analysis

ConclusionsTBLC is more effective in obtaining adequate samples for NGS analysis than EBUS ‐TBNA. TBLC should be performed to obtain adequate samples for NGS analysis in lung cancer patients with target lesions in lung fields, even if they have lymphadenopathy.Key pointsSignificant findings of the study The mean number of genes that could not be evaluated was significantly lower in TBLC samples than in EBUS ‐TBNA samples (0.9 vs. 10.3,P = 0.024). TBLC could obtain adequate samples with a high concentration of uncrushed tumor cells for NGS.What this study adds To obtain samples for NGS analysis, the use of TBLC should be aggressively considered in lung ‐cancer patients with target lesions located in lung fields, even if they have lymphadenopathy.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research