Detection of Parental Contribution to Molar Genome Leads to Diagnosis of Recurrent Hydatidiform Mole in a Family with NLRP7 Variants.

Conclusion: The genotype study should be obtained for patients of CHM, even in their first pregnancy, followed by genetic screening for maternal-effect variants in those with biparental moles. This strategy will identify patients in their first pregnancy with HM that have a decreased chance for a normal pregnancy, to allow genetic counseling, perhaps utilizing a donor egg. PMID: 33252287 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33252287?dopt=Abstract

Source: Fetal and Pediatric Pathology - December 3, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research