Efficacy and Safety of Perindopril Arginine + Amlodipine in Hypertension

To study the efficacy and safety of a new combination of perindopril arginine and amlodipine besylate, 837 subjects were enrolled in a three-arm, prospective, 59-center, randomized clinical trial. For 42 days, subjects (average seated blood pressure [BP] 158±12/101±5 mm Hg, age 52±10 years, 52% male, 34% black, 20% diabetic) received amlodipine/perindopril arginine (10/14 mg/d), perindopril erbumine 16 mg/d, or amlodipine 10 mg/d. Goal BP was < 140/90 or < 130/80 mm Hg in diabetics, per JNC 7 guidelines.
Source: Journal of the American Society of Hypertension - Category: Cardiology Authors: Source Type: research